Invited Commentary: Does Neonatal Hyperbilirubinemia Cause Asthma?

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Invited Commentary Invited Commentary: Does Neonatal Hyperbilirubinemia Cause Asthma?

In an analysis of data from the US Collaborative Perinatal Project, Huang et al. (Am J Epidemiol. 2013; 178(12):1691–1697) report an association between neonatal total serum bilirubin levels and childhood asthma. To consider the implications of this finding, we need to evaluate whether the association is causal. The results do not appear to be due to chance or any obvious biases. It is likely t...

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Invited commentary: asthma surveillance in US children.

Asthma is a highly prevalent and disabling disease of childhood. Data from national surveys indicate that 5–11 percent of children and adolescents in the United States— totaling over 4 million persons—have physician-diagnosed asthma (1–4). It is the most prevalent cause of childhood disability, with 1.4 percent of US children having disabling asthma (5). These data leave little room to doubt th...

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Neonatal hyperbilirubinemia.

Care of the high-risk neonate usually refers to the low-birth-weight infant or the sick term newborn. Whereas hyperbilirubinemia is certainly a matter of concern in these infants, the decisions that must be made regarding jaundice in the high-risk neonate are, in general, less complex than those that must be made for the healthy full-term infant. For the term and near-term infant, shorter hospi...

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Neonatal hyperbilirubinemia

Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life. Low levels of bilirubin exert antioxidant effects, but some neonates may develop very high levels of unconjugated bilirubin (UCB), with an increase of the unbound free fraction (Bf), able to diffuse through the blood brain barrier. Amount and duration of hyperbilirubinemia and the neurodevelopmental age (...

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Henna: a potential cause of oxidative hemolysis and neonatal hyperbilirubinemia.

OBJECTIVE To evaluate the in vitro oxidation potential of lawsone (2-hydroxy-1,4 naphthoquinone). Lawsone is a chemical present in henna, the crushed leaves of which are used worldwide as a cosmetic agent to stain the hair, skin, and nails. METHODOLOGY Venous blood from glucose-6-phosphate dehydrogenase (G6PD)-normal and G6PD A- subjects were incubated with various amounts of lawsone for 2 ho...

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ژورنال

عنوان ژورنال: American Journal of Epidemiology

سال: 2013

ISSN: 0002-9262,1476-6256

DOI: 10.1093/aje/kwt249